• The following are the supplementary data related to

  2023-09-21

  

  The following are the supplementary data related to this article. Conflict of interest Acknowledgements Disclosure of interest Introduction Since the introduction of platinum-based chemotherapy, metastatic testicular cancer has become a curable disease and most testicular cancer patient

• The altered frequency of CD T cells in LO mice

  2023-09-21

  

  The altered frequency of CD4+ T Amikacin in 5-LO−/− mice led us to hypothesize that these leukocytes could be exerting a primary control of the inflammatory response. In fact, the lack of 5-LO resulted in the accumulation of CD4+CD25+ cells expressing Treg markers. It is plausible to speculate that

• TLX may promote survival and prevent

  2023-09-21

  

  TLX may promote survival and prevent apoptosis in NB GF 109203X [12]. Here, we ask whether the survival-promoting effects of TLX are mediated by Apoptosis Signal-regulating Kinase-1 (ASK1, MAP3K5). ASK1 is a member of the Mitogen-Activated Protein (MAP) kinase family and it preferentially activates

• Octreotide acetate Most of lipid lowering agents have many t

  2023-09-21

  

  Most of lipid-lowering agents have many therapeutic problems with severe side effects, while dietary fibers as lipid lowering therapy are safer. Chitosan (CS) is a dietary fiber biodegradable, biocompatible and has many health benefits including wound healing, antiinflammatory, anti-cancers, immune-

• Furthermore we also found that the basic

  2023-09-21

  

  Furthermore, we also found that the basic level of ROS was markedly lower in mtDNA-reduced SW480 carbenoxolone synthesis than that in the parent cells. Endogenous ROS is most notably produced at the sites of complex I and complex III [5], it might be plausible that the decreased quantity of ROS obs

• Several strategies have been employed to

  2023-09-21

  

  Several strategies have been employed to design and engineer peptide biosensors of kinase activity, which are quite different from the strategies developed to generate genetically encoded KARs. In all cases, AZD1152 induces changes in the spectral properties of the fluorophore(s) incorporated into t

• Whereas allostery in the cell is relatively

  2023-09-21

  

  Whereas allostery in the β cell is relatively understudied, significant progress has been made in understanding the physiology and mechanistic biology of how AMPK and its upstream kinases govern β cell function. LKB1 phosphorylates AMPKα at Thr172 [21], and loss of LKB1 in β cells abolishes phosphor

• br AKT signaling is essential during early dorsal patterning

  2023-09-20

  

  AKT signaling is essential during early dorsal patterning, neural crest induction and maturation AKT signaling modulates EMT and migration of the neural crest cells The defining feature of NC cells is their delamination from the dorsal neural epithelium. At the end of neurulation, mature premi

• Multiple ASD susceptibility genes converge on cellular pathw

  2023-09-20

  

  Multiple ASD susceptibility genes converge on cellular pathways that intersect at the postsynaptic site of glutamatergic synapses (Bourgeron, 2015; Peca & Feng, 2012), the development and maturation of synaptic contacts (Gilman et al., 2011) or synaptic transmission (Li et al., 2014). The majority o

• In summary we could identify and experimentally

  2023-09-20

  

  In summary, we could identify and experimentally confirm two novel SBEs within the 5-LO promoter and we were able to demonstrate that TGFβ and SMADs stimulate 5-LO promoter activity. Moreover, an elevated 5-LO expression has been linked to different forms of leukaemia. Therefore, the influence of ML

• lactacystin mg Additionally in a previous transgenic model

  2023-09-20

  

  Additionally, in a previous transgenic model with autotaxin under the control of the MMTV-LTR promoter, aberrant expression of human autotaxin caused late-onset, metastatic breast cancer [5]. The AT-ATX transgenic model is analogous to the previous one because ∼30% of all spontaneous tumors appeared

• Aurora A the polar kinase is located at

  2023-09-20

  

  Aurora A the ’polar kinase’ is located at the centrosome and is required for its maturation, division, for the mitotic spindle assembly and entry into mitosis., Mutation or transcriptional silencing of Aurora A impairs centrosome maturation and separation, leads to mono/multipolar spindles, to delay

• br Introduction In the past

  2023-09-20

  

  Introduction In the past two decades, graphene and graphene based nanomaterials with unique physicochemical properties have attracted great attentions in many fields including biomedicine and biotechnology. Graphene oxide (GO) and its derivatives have shown promising potential as biological and c

• Based on the results of studies done

  2023-09-20

  

  Based on the results of studies done to-date, there are three characteristics that make a letrozole-based protocol attractive for use in cattle: 1) it is steroid-free, 2) it is cost-effective and requires a shorter time and fewer animal handlings than conventional methods (Table 1), and 3) it may ha

• APJ receptor expression is altered in

  2023-09-20

  

  APJ receptor expression is altered in various cardiovascular diseases, and both increases as well as decreases in APJ receptor expression have been reported. A decrease in mRNA and protein levels of APJ receptors was observed in patients with ischemic heart disease or idiopathic dilated cardiomyopat

14525 records 248/969 page Previous Next First page 上5页 246247248249250 下5页 Last page