• br Acknowledgements br Introduction Double

  2023-09-06

  

  Acknowledgements Introduction Double-stranded DNA breaks (DSBs) are among the most deleterious DNA lesions that threaten genomic integrity. DSBs are generated not only by exogenous DNA-damaging agents but also by normal cellular processes such as V(D)J recombination, meiosis, and DNA replicati

• The compounds containing beryllium act as

  2023-09-06

  

  The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be daunorubicin []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extremely strong bidentate

• Insulin is the central hormone involved in the control

  2023-09-06

  

  Insulin is the central hormone involved in the control of glucose and lipid metabolism. Other nonmetabolic effects of insulin are intensively studied as well. Activation of insulin receptor not only promotes glucose uptake, protein synthesis, and inhibits lipid metabolism, but also is crucial for re

• Sixth significant progress has been

  2023-09-06

  

  Sixth, significant progress has been made during the last few years regarding the molecular mechanisms underlying the activation of AMPK and this should aid to develop more potent and specific compounds. Information from crystallographic structures combined with computer-based drug design hold promi

• br Discussion Missense mutations transversions of the first

  2023-09-06

  

  Discussion Missense mutations (transversions) of the first nucleotide of the phenylalanine levosimendan at position 1174 (F1174) of the anaplastic lymphoma kinase gene can result in substitutions to leucine or valine (F1174L/V) while missense mutation (transversion) of the second nucleotide of t

• GLP-2 (rat) Perhaps the discovery of this linkage has served

  2023-09-06

  

  Perhaps the discovery of this linkage has served to catapult much of the work on ABCA1, leaving its family member in need of a relationship with a defined human pathology. In this regard, there is by now a quite mature literature that suggests that ABCA2 may have been overlooked in terms of its impo

• Anacardic acid Given the profound expression of HT A and

  2023-09-06

  

  Given the profound Anacardic acid of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes are reversib

• br Funding br Introduction The interest in the

  2023-09-06

  

  Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a

• Eicosanoids are locally acting signaling lipids

  2023-09-06

  

  Eicosanoids are locally acting signaling lipids that are produced from C20 polyunsaturated fatty acids (PUFAs), including arachidonic c-Myc tag (AA, C20:4), eicosapentaenoic acid (C20:5) and eicosatrienoic acid (C20:3) (Dennis and Norris, 2015; Funk, 2001; Stables and Gilroy, 2011). According to the

• As mentioned above variation of the

  2023-09-05

  

  As mentioned above, variation of the A-ring was undertaken in order to improve microsomal stability and kinase selectivity relative to mma f (). 1-Imidazole-2-carboxamides with substitution at the 4-position (–) were mostly tolerated with 4-cyano-imidazole-2-carboxamide () having comparable inhibito

• Aurora A overexpression is also

  2023-09-05

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer Erastin synthesis [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene products an

• exemplifies three of the compounds investigated in the selec

  2023-09-05

  

  exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC monensin as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or degradation products. A

• The tumor suppressor function of LOX

  2023-09-05

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

• br Conflicts of interest br Financial support This work was

  2023-09-05

  

  Conflicts of interest Financial support This work was supported by grants from the Fondazione Cariplo [Grant number 2011-0463] (Carini); and by Funds for Original Research of the Università del Piemonte Orientale (2016, Project: Carini-Boldorini). The sponsors had no involvement in study desig

• br Declaration of interest br Funding br Introduction The

  2023-09-05

  

  Declaration of interest Funding Introduction The endocrine disruptor bisphenol A (BPA) is a high-production chemical used in several consumer products, including polycarbonate bottles, epoxy resins, dental sealants, and thermal paper receipts (Geens et al., 2012). Importantly, BPA monomers

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