• br Ataxia telangiectasia and Rad

  2023-02-01

  

  Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma

• As regards LEPR Sun et al showed

  2023-02-01

  

  As regards LEPR, Sun et al. showed that the rs1137101-223A > G polymorphism influences the effectiveness of simvastatin on plasma HDL-C levels in CHD patients [35]. In accordance with the results of García-Bermúdez et al., however, no such an association exists between leptin rs2167270 (G > A) poly

• br Introduction Hepatocellular carcinoma HCC is the third le

  2023-02-01

  

  Introduction Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related death worldwide and accounts for 70–85% of all liver cancer diagnoses [1]. In East and South-East Asia, the occurrence of HCC and the related number of fatalities have gradually increased in recent decades [2

• br The lipoxygenase pathway in diseases of the nervous

  2023-02-01

  

  The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic Aliskiren Hemifumarate and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the funct

• br LO synaptic integrity and memory Interestingly several gr

  2023-02-01

  

  12/15LO, synaptic integrity, and memory Interestingly, several groups have found that 12/15LO directly modulates synaptic function. Normandin and colleagues reported that pharmacological inhibition of 12/15LO modulates rat hippocampal long-term depression (LTD), a process by which neuronal synapt

• Estudos de biomarcadores mostram que as concentra es

  2023-02-01

  

  Estudos de biomarcadores mostram que as concentrações de proteína amiloide no LCR estão inversamente relacionadas com o grau de doença de Alzheimer. No entanto, quer as placas amiloides quer a diminuição da proteína amiloide podem ser encontradas em idosos sem clínica de disfunção cognitiva, pelo qu

• br Methods br Results br Discussion By following a

  2023-02-01

  

  Methods Results Discussion By following a large cohort of older persons for up to 11 years, we found that subjects with more degraded FR in motor activity (i.e., weaker temporal activity correlations at time scales Docetaxel pathologies affect diverse clinical phenotypes and are related to

• In this study we demonstrated that DRR protein

  2023-02-01

  

  In this study, we demonstrated that DRR1 protein level in GBM tissues was significantly higher compared to normal Pyroxamide tissues. This data suggested that DRR1 might play a role in the tumorigenesis of glioma. To investigate whether DRR1 could accurately predict the outcome in patients with gli

• An important and well documented pathway involved

  2023-02-01

  

  An important and well-documented pathway involved in cellular growth and proliferation is the mTOR-mediated synthesis of proteins and lipids [7,13,14]. Although found to be tissue specific or context specific regulation, it has always been observed that either one or both the mTOR complexes regulate

• br Conclusions br Acknowledgments The authors are thankful t

  2023-02-01

  

  Conclusions Acknowledgments The authors are thankful to Hugo Santos, Olga Martinez and Ricardo Lacerda for the technical assistance provided in the maintenance of the aquaria. This work was supported by national funds, through FCT and co-funded by the European Regional Development Fund (ERDF)

• To help ensure the fidelity of mitosis and

  2023-02-01

  

  To help ensure the fidelity of mitosis and cytokinesis cells monitor these processes and delay cell cycle progression in response to certain defects. The spindle assembly checkpoint (SAC) is a surveillance system which delays Tivantinib onset until a bipolar spindle has been correctly assembled (Lar

• Production of reactive oxygen species ROS during RSV

  2023-01-31

  

  Production of reactive oxygen species (ROS) during RSV infection is one the important ways that neutrophils can injure the lungs [2], [24], [25]. Lipoxygenases are considered as an important source of producing ROS inside the Wnt agonist 1 [26]. Several studies have indicated that the 12/15-LOX is a

• ARG I is one of the most important mammalian enzymes

  2023-01-31

  

  ARG I is one of the most important mammalian enzymes responsible for nitrogen metabolism since it comprises the main route for the elimination of excess nitrogen resulting from amino Nelfinavir and nucleotide metabolism [18]. ARG I deficiency leads to hyperargininemia, characterized by progressive n

• To further address the mechanism of Didox s

  2023-01-31

  

  To further address the mechanism of Didox’s suppressive effects on mast cell activation, FceRI receptor MAZ51 and downstream transcription factor induction were assessed. We found that Didox had no effect on FceRI surface expression, and thus concluded that Didox effects must be occurring downstrea

• Plant defensins Vriens et al

  2023-01-31

  

  Plant defensins (Vriens et al., 2014) and linear AMPs (Domingues et al., 2015, Liu et al., 2008) have been shown to present several modes of action. Among these different mechanisms, permeabilization of the fungal membrane has been described as a secondary effect of plant defensin action (Vriens et 

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