• AMPK is a cellular energy sensor

  2023-02-06

  

  AMPK is a cellular energy sensor that is phosphorylated in response to high intracellular ADP levels to increase GLUT4 translocation into the cell, and subsequently, increase intracellular glucose levels to provide substrate to replenish ATP levels [25]. In metabolic syndrome, sequestration of plasm

• 2365 br Concluding remarks br Conflict of

  2023-02-06

  

  Concluding remarks Conflict of interest Acknowledgment This work was supported by the H.E.B. Endowed Chair in Marine Science (to P.T.) and University of Texas Marine Science Institute endowment-supported scholarships (to A.C). Introduction Disorders of sex development (DSD) are defined

• Vatalanib br Conclusion br Acknowledgement This study was su

  2023-02-06

  

  Conclusion Acknowledgement This study was supported by NIH/NINDSR01 NS036812-16. Introduction Lipoxygenases (LOXs) are a heterogeneous family of enzymes that catalyze the peroxidation of polyunsaturated fatty acids (PUFAs). By oxidizing free PUFAs, they were shown to contribute to the gene

• br Results br Discussion Today enzymes play

  2023-02-03

  

  Results Discussion Today, enzymes play important roles in various fields. A good assay for enzyme activity is of great value, especially when it has good specificity, sensitivity, reproducibility and economy. ADK is the first identified enzyme in the metabolic pathway of adenosine salvage [15,

• Many metalloenzyme inhibitors consist of two chemical compon

  2023-02-01

  

  Many metalloenzyme inhibitors consist of two chemical components: the MBG, the portion of the inhibitor designed to bind to the metal, and the scaffold, the portion of the inhibitor recognized by the amino Bcl Family Set I residues that form the substrate-binding site of the metalloenzyme. The MGB

• It was previously demonstrated that

  2023-02-01

  

  It was previously demonstrated that dissociation of the V-ATPase in response to glucose depletion in yeast requires an intact microtubular network [28] and a catalytically active enzyme [29]. Interestingly, mutations in the non-homologous region of the catalytic subunit A are able to block dissociat

• br Ataxia telangiectasia and Rad

  2023-02-01

  

  Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma

• As regards LEPR Sun et al showed

  2023-02-01

  

  As regards LEPR, Sun et al. showed that the rs1137101-223A > G polymorphism influences the effectiveness of simvastatin on plasma HDL-C levels in CHD patients [35]. In accordance with the results of García-Bermúdez et al., however, no such an association exists between leptin rs2167270 (G > A) poly

• br Introduction Hepatocellular carcinoma HCC is the third le

  2023-02-01

  

  Introduction Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related death worldwide and accounts for 70–85% of all liver cancer diagnoses [1]. In East and South-East Asia, the occurrence of HCC and the related number of fatalities have gradually increased in recent decades [2

• br The lipoxygenase pathway in diseases of the nervous

  2023-02-01

  

  The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic Aliskiren Hemifumarate and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the funct

• br LO synaptic integrity and memory Interestingly several gr

  2023-02-01

  

  12/15LO, synaptic integrity, and memory Interestingly, several groups have found that 12/15LO directly modulates synaptic function. Normandin and colleagues reported that pharmacological inhibition of 12/15LO modulates rat hippocampal long-term depression (LTD), a process by which neuronal synapt

• Estudos de biomarcadores mostram que as concentra es

  2023-02-01

  

  Estudos de biomarcadores mostram que as concentrações de proteína amiloide no LCR estão inversamente relacionadas com o grau de doença de Alzheimer. No entanto, quer as placas amiloides quer a diminuição da proteína amiloide podem ser encontradas em idosos sem clínica de disfunção cognitiva, pelo qu

• br Methods br Results br Discussion By following a

  2023-02-01

  

  Methods Results Discussion By following a large cohort of older persons for up to 11 years, we found that subjects with more degraded FR in motor activity (i.e., weaker temporal activity correlations at time scales Docetaxel pathologies affect diverse clinical phenotypes and are related to

• In this study we demonstrated that DRR protein

  2023-02-01

  

  In this study, we demonstrated that DRR1 protein level in GBM tissues was significantly higher compared to normal Pyroxamide tissues. This data suggested that DRR1 might play a role in the tumorigenesis of glioma. To investigate whether DRR1 could accurately predict the outcome in patients with gli

• An important and well documented pathway involved

  2023-02-01

  

  An important and well-documented pathway involved in cellular growth and proliferation is the mTOR-mediated synthesis of proteins and lipids [7,13,14]. Although found to be tissue specific or context specific regulation, it has always been observed that either one or both the mTOR complexes regulate

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