• br Acknowledgements br Introduction The angiogenic ocular co

  2024-10-10

  

  Acknowledgements Introduction The angiogenic ocular conditions represent the most common cause of blindness in developed countries [1]. It can affect all ages, for example, retinopathy of prematurity (ROP) in infants [2], [3], diabetic retinopathy (DR) [4] in working age adults and age-relate

• In conclusion our study has

  2024-10-10

  

  In conclusion, our study has identified a splice site 5-alpha reductase inhibitors (c.1769-1G > C) in the AR gene from two patients with complete androgen insensitivity syndrome. The c.1769-1G > C mutation may provide us new insights into the molecular mechanism involved in splicing defects underlyi

• Testosterone can be converted into

  2024-10-10

  

  Testosterone can be converted into estrogens by aromatase action. Aromatase is encoded by CYP19, belongs to cytochrome P450 superfamily, and synthesizes estradiol (E2) and estrone (E1) from testosterone and androstenedione respectively (Fig. 1). Aromatase is expressed in the ORS of anagen hair folli

• br Acknowledgments br Introduction Alzheimer

  2024-10-10

  

  Acknowledgments Introduction Alzheimer's disease (AD) is a severe neurodegenerative disorder primarily affecting the elderly population. Senile plaques in the brain, one of the pathological hallmarks of AD, are formed by the accumulation of aggregated β-amyloid (Aβ) with an extensive β-sheet s

• The first and the best characterized mechanism of receptor d

  2024-10-10

  

  The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic Sunitinib Malate receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additional molecu

• To elucidate this relationship we developed a spatial model

  2024-10-10

  

  To elucidate this relationship, we developed a spatial model of Ca-influx through N-methyl-D-aspartate receptor (NMDAR), CaMKII/PP1 activation, and AMPAR insertion in a realistic spine geometry. Using this model, we show that i) variables in membrane voltage mediated Ca-influx, particularly the numb

• A unique finding in this study is that

  2024-10-10

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic Go 6983 for substrate, can regulate CREB phosphoryation in the context of Alzheimer's d

• As we previously observed in

  2024-10-10

  

  As we previously observed in the NSFT (Fukumoto et al., 2014), the effect of LY341495 in the FST was also inhibited by a 5-HT1A receptor antagonist, indicating the role of the 5-HT1A receptor in the actions of LY341495. Among the 5-HT1A receptors, which exist both presynaptically and postsynapticall

• Further evidence for ACh GABA cotransmission had also

  2024-10-09

  

  Further evidence for ACh/GABA cotransmission had also been observed in the cortex. Extensive axonal arborization from cholinergic BF neurons exists throughout the cortical layers, allowing direct observation of cholinergic synaptic terminals. One study in the visual cortex of cat examined immunolabe

• br Co http www apexbt com

  2024-10-09

  

  Conclusions This paper is the first meta-analysis about the association between SRD5A2 V89L polymorphism and hypospadias risk. The results of this meta-analysis have revealed that V89L polymorphism definitely increases the risk of hypospadias, and the C allele is a genetic risk factor for hypospa

• CUDC-907 We demonstrate a role for low

  2024-10-09

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 CUDC-907 and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA levels

• Protein protein interaction networks are an important ingred

  2024-10-09

  

  Protein–protein interaction networks are an important ingredient for the system-level understanding of cellular processes. Such networks can be used for filtering and assessing functional genomics data and for providing an instinctive platform for annotating structural, functional and evolutionary p

• Therefore the rational design of target compounds is based o

  2024-10-09

  

  Therefore, the rational design of target compounds is based on the hybrid of attractive phenotypic bis-indole (5, Fig. 1) and sulfonamide moieties, in which the indole core might anticipate in hydrophobic interaction, and the functionality of sulfonamide group may involve in H-bonding with the site

• Maduramicin is a polyether ionophore antibiotic that

  2024-10-09

  

  Maduramicin is a polyether ionophore antibiotic that has the smallest margin of safety between the maximum authorized dosage and the minimum toxic concentration. Clinical signs of maduramicin intoxication are similar to that of other ionophores, often causing feed refusal, anorexia, respiratory dist

• br Acknowledgements This work was supported by

  2024-10-09

  

  Acknowledgements This work was supported by a grant from the National Science Foundation (IOS- 1353366), the Hatch Program of the National Institute of Food and Agriculture (VA-135908) and the Virginia Agricultural Experiment Station, to G.P. Introduction With steadily rising number of affect

14392 records 40/960 page Previous Next First page 上5页 3637383940 下5页 Last page