• Exposure to cisplatin with ATR inhibitor resulted

  2024-12-13

  

  Exposure to cisplatin with ATR inhibitor resulted in an increase in cisplatin-DNA adducts, especially in cells with ATM deficiency. This finding indicates that suppressing ATR-Chk1 signaling with VE-822 enhances cisplatin activity by enabling the drug to form DNA adducts. Therefore, VE-822 may incre

• This study evaluated the anti tumor influences of

  2024-12-13

  

  This study evaluated the anti-tumor influences of LA against HepG2 Closantel Sodium in vivro, and investigated the molecular mechanisms of inducing apoptosis. Overall, our studies suggested that LA is a promising anti-cancer drug and a possible novel therapeutic agent directed toward the mitochondri

• br Material and methods br Results br Discussion In order

  2024-12-13

  

  Material and methods Results Discussion In order to find new and improved ways of treating type 2 diabetes (T2D) and other related conditions it is vital that investigators gain a more in-depth understanding of the effects that anti-diabetic treatments, such as TZDs, have on molecules impli

• br Perspectives br Acknowledgments This investigation

  2024-12-12

  

  Perspectives Acknowledgments This investigation was supported by a Research Grant 2010/01385-5 from FAPESP (Sao Paulo Research Foundation, Brazil). P.F.S. was recipient of a CNPq (National Council for Scientific and Technological Development, Brazil) productivity grant. R.F.A. was recipient of

• ALK fusion positive NSCLC is clinically actionable because

  2024-12-12

  

  ALK fusion-positive NSCLC is clinically actionable because it can be targeted by several FDA-approved drugs, including the first generation TKI crizotinib, which is a dual inhibitor to MET and ALK [15], and the second generation inhibitors, alectinib and ceritinib, both of which are highly-selective

• br Materials and methods br

  2024-12-12

  

  Materials and methods Results and discussion First, we examined whether hypothalamic Akt-mediated signaling pathways are regulated postprandially in chickens. Refeeding significantly (P PLX7904 concentrations significantly increased in chicks after 1 h of refeeding (958 ± 245% of 24 h-fasting

• The PAS domains of AHR

  2024-12-12

  

  The PAS domains of AHR consist of two regions, PAS-A and PAS-B, which function as interfaces for dimerization with ARNT and for ligand binding, respectively [14]. Although both the bHLH and the PAS-A domains have been shown to be involved in dimerization with ARNT, a recent report suggests that only

• Derivatives of M that possess either an alkyne

  2024-12-12

  

  Derivatives of (+)-M100907 that possess either an alkyne or an azide have been synthesized. The most active enantiomer was obtained by resolution of a relatively early intermediate in the synthesis. The ability of these nos abbreviation to maintain 5-HTR antagonist properties as (+)-M100907 was dem

• The observation that vortioxetine blocks

  2024-12-12

  

  The observation that vortioxetine blocks 5-HT-induced currents in 5-HT3 receptor-expressing oocytes suggests that vortioxetine acts to functionally antagonize these receptors, and is in line with previously published data (Bang-Andersen et al., 2011). For example, Mørk et al. (2012) demonstrated tha

• While A Rs communicate mainly

  2024-12-12

  

  While A1Rs communicate mainly with the D1R subtype [36], A2AR and D2R interaction occurs mainly in basal ganglia. D2Rs colocalizes with A2ARs in this ac 723 synthesis area where they are preferentially localized postsynaptically in the soma and dendrites of GABAergic striatopallidal neurons [69]. T

• A more versatile cellular delivery system for adenosine

  2024-12-12

  

  A more versatile cellular delivery system for adenosine was generated by engineering mouse embryonic stem cells to lack both 87 8 of Adk (Fedele et al., 2004). Using a step-wise differentiation protocol (Okabe et al., 1996) Adk−/− ES cells were differentiated into transplantable adenosine-releasing

• br Acknowledgement br Introduction There has been

  2024-12-12

  

  Acknowledgement Introduction There has been great progress in the treatment of autoimmune disease during the past several decades. However, the majority of autoimmune diseases have no known cure. B lymphocytes and autoantibodies play important roles in many autoimmune diseases, including rheum

• Drug resistance development often involves structurally un r

  2024-12-12

  

  Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 CGP 53353 mg are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, associate

• br Materials and methods br Results br Discussion

  2024-12-12

  

  Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o

• Recent studies have demonstrated significant cross talk

  2024-12-11

  

  Recent studies have demonstrated significant cross-talk between XRCC1 (a key player in phospholipase c inhibitor excision repair (BER) and single strand break repair) and DDR [30], [31], [32]. ATM and DNA-PKcs are known to be involved in the phosphorylation of XRCC1 to promote BER [30], [31]. We ha

14375 records 6/959 page Previous Next First page 上5页 678910 下5页 Last page