• Although both DNA DSBs and DNA

  2021-04-06

  

  Although both DNA DSBs and DNA-PK activity increase with aging in skeletal muscle (Figure 1), we cannot conclude that aging-associated increase in DNA-PK activity is solely mediated by chromosomal breaks, as DNA-PK is also activated independently of chromosomal breaks by ROS (Li et al., 2014), which

• br Acknowledgements This work was supported by a Grant

  2021-04-06

  

  Acknowledgements This work was supported by a Grant for the Program for the Strategic Research Foundation at Private Universities S1101017 organized by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan and JSPS KAKENHI Grant Numbers JP22560209 and JP5K05842. The

• br Introduction Coping with DNA damage is possible thanks to

  2021-04-06

  

  Introduction Coping with DNA damage is possible thanks to surveillance mechanisms (checkpoints), that detect the problem and promote its solution [1], [2], and to repair and tolerance pathways that remove the lesions or reduce the damage consequences [3], [4]. Failures in these processes have a h

• br Funding br Conflict of interests br Introduction DAG is

  2021-04-06

  

  Funding Conflict of interests Introduction DAG is generated by the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) by PtdIns-specific phospholipase C (PLC) enzymes [1]. Remaining in the membrane, it binds proteins with cysteine-rich, C1 domains, and activates several of

• We also performed a correlation analysis independent of anno

  2021-04-06

  

  We also performed a correlation analysis independent of annotated gene sets to identify potentially novel genes that are co-expressed with DHODH. Using the top 100 DHODH co-expressed genes in COAD, LGG, STAD, and PAAD diseases, we identified four common genes across all four diseases (Fig. 9). These

• DDR plays a crucial role in regulating

  2021-04-06

  

  DDR2 plays a crucial role in regulating a wide variety of fundamental cellular processes, including cell proliferation, differentiation, and adhesion [17], [28], [29], [30]. The authors revealed compromised cell migration in DDR2-silenced fibroblasts exposed to Ang II, most likely due to the loss of

• One possible explanation for differences in

  2021-04-06

  

  One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul

• In present study we measured the

  2021-04-06

  

  In present study, we measured the methylation and 4-aminopyridine sale levels of CDKL2 in HCC tissues and cell lines. Meanwhile, correlations between the methylation and mRNA expression, clinicopathological features were evaluated. Materials and methods Results Discussion DNA methylation

• Compounds were prepared via the routes shown in

  2021-04-06

  

  Compounds were prepared via the routes shown in , varying the sequence of reactions to install the thiazole or the phenyl ring at the end of the synthesis (pyridyl examples were prepared using similar chemistry). The aminothiazole building blocks were prepared as shown in . 5-Aminothiazole was prep

• br Materials and methods br Results br Discussion Neointimal

  2021-04-02

  

  Materials and methods Results Discussion Neointimal VSMC accumulation contributes considerably to vessel occlusion observed in both autologous vein graft degeneration [1], [2] and in-stent restenosis [26], [27]. In this study, the potential for retarding VSMC proliferation and hence amelior

• br Conflict of interest br Acknowledgements This study

  2021-04-02

  

  Conflict of interest Acknowledgements This study was supported by the National Natural Science Foundation of China (No.31571839), the Chinese Ministry Program for New Century Excellent Talents in University (NCET-12-0865), and Special Fund for Agro-scientific Research in the Public Interest (N

• ClC is a member of

  2021-04-02

  

  ClC-3 is a member of the voltage-gated chloride channel superfamily and has many roles in cell proliferation, apoptosis, Firefly Luciferase australia progression and so on (Dai et al., 2005). A growing number of studies showed that ClC-3 encoded a volume-regulated Cl− channel (ICl,Vol) in heart, th

• Thus the understanding of the various mechanisms of action

  2021-04-02

  

  Thus, the understanding of the various mechanisms of action of estrogen and SERMs is an important medical challenge and could help to develop an “ideal” SERM, preserving the beneficial effects of estrogen in the bone and urogenital system, and reducing the unwanted side effects, mainly increased ris

• Although many of the genetic changes

  2021-04-02

  

  Although many of the genetic changes remain to be elucidated, there is evidence to support a difference in incidence and rate of rupture of cerebral aneurysms between men and women, and between pre- and postmenopausal women, suggesting that aneurysm formation may be affected by hormonal changes.18,

• The indigenous populations living at high

  2021-04-02

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human tryptophan hydroxylase to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopulmonary

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