• Our previous data showed that microsomal VgDGATs have higher

  2020-08-04

  

  Our previous data showed that microsomal VgDGATs have higher specificity for acyl substrates containing Va (Yu et al., 2006). Here, analysis of lipid Sodium ascorbate in transgenic soybean seeds and Stokesia and Vernonia seeds demonstrated that the Va-PC level is higher while Va-TAG is lower in the

• Introduction Cysteinyl leukotrienes CysLTs LTC LTD and LTE a

  2020-08-03

  

  Introduction Cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, are 5-lipoxygenase pathway metabolites of arachidonic nisoldipine and deeply involved in bronchial asthma via activation of CysLT1 receptors [1], [2]. Specific CysLT1 receptor antagonists, including pranlukast [3], [4] and monteluk

• Drug induced toxicity is caused either by parent compounds o

  2020-08-03

  

  Drug-induced toxicity is caused either by parent compounds or by their reactive metabolites that are generated through biotransformation primarily in the liver (Srivastava et al., 2010). The cytochrome P450 (CYP) superfamily members contribute to approximately 80% of this process (Evans and Relling,

• In preliminary radiolabeling experiments F

  2020-08-03

  

  In preliminary radiolabeling experiments, [F] was prepared via the alkylation of precursor with [F]fluorobenzyl bromide ([F], , ). Alkylation leading to [F] was performed in radiochemical yield (RCY) of 13% (HPLC incorporation yield, non-decay corrected) in the presence of CsCO and tetrabutylammoni

• br Introduction Fibrosis progression is the common consequen

  2020-08-03

  

  Introduction Fibrosis progression is the common consequence of most chronic liver diseases and histologic examination of a liver biopsy specimen is the reference standard for the assessment of liver fibrosis. However, liver biopsy is burdened by invasiveness and low degree of acceptance by patien

• Despite the weak and transient nature of E E

  2020-08-03

  

  Despite the weak and transient nature of E2–E3 interactions, this binding is required for the transfer of ubiquitin to the substrate. The low affinity characteristics of this interaction may be due to the fact that E2s use the same surface to interact with E1s and E3s, and hence while binding to an

• The ubiquitin proteasome system Ub P is

  2020-08-03

  

  The ubiquitin–proteasome system (Ub–P) is the main cellular machinery for protein turnover in eukaryotic cells (Glickman and Ciechanover, 2002). Degradation by Ub–P involves two steps. Target proteins are selectively, specifically, and covalently attached to ubiquitin (Ub) chains, followed by Ub-tag

• It is now realized more and

  2020-08-03

  

  It is now realized more and more that proper HT contributes to the well-being and function of women who have lost their ovarian function, improves or maintains physical and mental activity, and contributes to the quality of life [6]. This is mainly determined by estrogens. In order to avoid undue ch

• In addition silencing of EWS FLI using antisense

  2020-08-03

  

  In addition, silencing of EWS–FLI1 using antisense DNA, siRNA or dominant negative methods markedly impairs Ewing sarcoma cell growth (Maksimenko & Malvy, 2005). From a therapeutic standpoint, the challenge is integrating this data into the preclinical and clinical development of new agents that ta

• br Experimental br Results and discussions br

  2020-08-03

  

  Experimental Results and discussions Conclusion Introduction The joining of DNA fragments using EG00229 is an essential process in gene cloning. One of the important parameters for performing DNA ligation efficiently is the temperature [1]. In the case of DNA strands with cohesive ends,

• br Discussion Type I collagen is

  2020-08-03

  

  Discussion Type I collagen is an important adhesive protein for use as scaffolding material for various tissue engineering applications [4], [5]. An understanding of how the various features of collagen matrices influence cell behavior is hence of great current interest [6]. Even for monotypic li

• br Cholinesterases and pharmacological effects of inhibitors

  2020-08-01

  

  Cholinesterases and pharmacological effects of inhibitors in the periphery It is now known that cholinergic signaling plays a vital role in controlling many peripheral functions including skeletal and smooth muscle contraction, autonomic postganglionic neuron activation, parasympathetic end-organ

• br Introduction Cholinesterases ChEs belong

  2020-08-01

  

  Introduction Cholinesterases (ChEs) belong to a superfamily of serine hydrolases which play a vital role through participating in termination of Timolol Maleate based signal transmission in neurosynaptic cleft (Ballard et al., 2005; Khaled et al., 2010). On the basis of substrate and inhibitor s

• br Materials and methods br Results

  2020-07-31

  

  Materials and methods Results These methods were validated according to U.S Food and Drug Administration guidelines for bioanalytical methods validation [38]. All probe-drugs tested in our CYP450 cocktail were evaluated for selectivity, sensitivity, linearity, precision, accuracy, recovery, ma

• The importance of EBI for B

  2020-07-31

  

  The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed Penciclovir Sodium synthesis and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An

14865 records 790/991 page Previous Next First page 上5页 786787788789790 下5页 Last page